HALFDANARSON et al. HEMATOLOGICAL MANIFESTATIONS OF CELIAC DISEASE

Celiac disease is a common systemic disorder which can have multiple hematological manifestations. Patients with celiac disease may present to hematologists for evaluation of various hematological problems prior to receiving a diagnosis of celiac disease. Anemia secondary to malabsorption of iron, folic acid and/or vitamin B12 is a common complication of celiac disease and many patients present with anemia or have anemia at the time of diagnosis. Celiac disease may also be associated with thrombocytosis, thrombocytopenia, leukopenia, venous thromboembolism, hyposplenism and IgA deficiency. Patients with celiac disease are at increased risk of being diagnosed with lymphoma, especially of the T-cell type. The risk is highest for enteropathy-type T-cell lymphoma (ETL) and B-cell lymphoma of the gut but extraintestinal lymphomas can also be seen. ETL is an aggressive disease with poor prognosis but strict adherence to a gluten free diet may prevent its occurrence. For personal use only. on April 12, 2017. by guest www.bloodjournal.org From